Water Permeability of Asymmetric Planar Lipid Bilayers : Leaflets of Different Composition Offer Independent and Additive Resistances to Permeation

Abstract

To understand how plasma membranes may limit water flux, we have modeled the apical membrane of MDCK type 1 cells. Previous experiments demonstrated that liposomes designed to mimic the inner and outer leaflet of this membrane exhibited 18-fold lower water permeation for outer leaflet lipids than inner leaflet lipids (Hill, W.G., and M.L. Zeidel. 2000. J… (More)

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