Water-Oil Partition Profiling of Ionized Drug Molecules Using Cyclic Voltammetry and a 96-Well Microfilter Plate System

  title={Water-Oil Partition Profiling of Ionized Drug Molecules Using Cyclic Voltammetry and a 96-Well Microfilter Plate System},
  author={Sorina M. Ulmeanu and Henrik Jensen and G{\'e}raldine Bouchard and Pierre-Alain Carrupt and Hubert H. Girault},
  journal={Pharmaceutical Research},
AbstractPurpose. A new experimental set-up for studying partitioning of ionizable drugs at the interface between two immiscible electrolyte solutions (ITIES) by amperometry is presented. The method is quite general, as it can be applied to any charged drug molecule. Methods. The procedure is based on 96-well microfilter plates with microporous filters to support 96 organic liquid membranes. The new methodology is first validated using a series of tetra-alkylammonium ions and subsequently used… 
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  • Abraham, Du, Platts
  • Chemistry, Medicine
    The Journal of organic chemistry
  • 2000
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