Was the initiation of translation in early eukaryotes IRES-driven?

@article{Hernndez2008WasTI,
  title={Was the initiation of translation in early eukaryotes IRES-driven?},
  author={Georgina Hern{\'a}ndez},
  journal={Trends in biochemical sciences},
  year={2008},
  volume={33 2},
  pages={
          58-64
        }
}
The initiation of translation in eukaryotes generally involves the recognition of a 'cap' structure at the 5' end of the mRNA. However, for some viral and cellular mRNAs, a cap-independent mechanism occurs through an mRNA structure known as the internal ribosome entry site (IRES). Here, I postulate that the first eukaryotic mRNAs were translated in a cap-independent, IRES-driven manner that was then superseded in evolution by the cap-dependent mechanism, rather than vice versa. This hypothesis… CONTINUE READING
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