Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden.

@article{Olsson2011WasTC,
  title={Was the C282Y mutation an Irish Gaelic mutation that the Vikings helped disseminate? HLA haplotype observations of hemochromatosis from the west coast of Sweden.},
  author={Karl Sigvard Olsson and Jan Konar and Inge Hoegh Dufva and Anne Ricksten and Ruma Raha-Chowdhury},
  journal={European journal of haematology},
  year={2011},
  volume={86 1},
  pages={75-82}
}
UNLABELLED The HLA-related hemochromatosis mutation C282Y is thought to have originated in Ireland in a person with HLA-A3-B14 and was spread by Vikings. Irish people with two HLA-A3 alleles had a high risk of hemochromatosis. In this study, from west Sweden, we wanted to test these hypotheses. METHODS HFE mutations in controls, bone marrow donors with HLA-A3/A3 and patients with hemochromatosis. HLA haplotypes, extended haplotype analysis and pedigree studies. RESULTS The allelic C282Y… CONTINUE READING

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