Warts, cancer and ubiquitylation: lessons from the papillomaviruses.

  • Peter M. Howley
  • Published 2006 in
    Transactions of the American Clinical and…

Abstract

Certain human papillomaviruses (such as HPV-16 and HPV-18) are associated with specific anogenital cancers, most notably cervical cancer. These viruses encode two oncoproteins, E6 and E7, which are expressed in the HPV positive cancers. E7 functions in cellular transformation, at least in part, through inactivation of pRB, and the other pRB related "pocket… (More)

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