Warmer preparation of hippocampal slices prevents synapse proliferation that might obscure LTP-related structural plasticity.

Abstract

The hippocampal slice is a popular model system in which to study the cellular properties of long-term potentiation (LTP). Synaptogenesis induced by exposure to ice-cold artificial cerebrospinal fluid (ACSF), however, raises the concern that morphological correlates of LTP might be obscured, especially in mature slices. Here we demonstrate that preparation… (More)

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