Warm autoimmune hemolytic anemia: recent progress in understanding the immunobiology and the treatment.

@article{Barros2010WarmAH,
  title={Warm autoimmune hemolytic anemia: recent progress in understanding the immunobiology and the treatment.},
  author={Melca Maria Oliveira Barros and Morris A. Blajchman and Jos{\'e} Orlando Bordin},
  journal={Transfusion medicine reviews},
  year={2010},
  volume={24 3},
  pages={195-210}
}
Autoimmune hemolytic anemia (AIHA) is defined as a condition associated with the increased destruction of red blood cells (RBCs) associated with the presence of IgG anti-RBC autoantibodies. The etiology underlying the pathogenesis of such autoantibodies is still uncertain. In the present article, we will discuss the postulated mechanisms that produce a breakdown of immunologic tolerance leading to warm AIHA including the possible roles of RBC autoantigens and the complement system, the lack of… CONTINUE READING