Warfarin pharmacogenetics: a rising tide for its clinical value.

@article{Johnson2012WarfarinPA,
  title={Warfarin pharmacogenetics: a rising tide for its clinical value.},
  author={Julie A. Johnson},
  journal={Circulation},
  year={2012},
  volume={125 16},
  pages={1964-6}
}
Warfarin has been in clinical use for nearly 60 years, and in 2010 there were 25 million prescriptions for warfarin in the United States. Although warfarin is highly efficacious, it has a narrow therapeutic window to achieve desired anticoagulation without excess risk of bleeding. Anticoagulation status is monitored with the International Normalized Ratio (INR), where the most common target INR is 2 to 3. Not only does warfarin exhibit a narrow therapeutic index, but there can be 10to 20-fold… CONTINUE READING
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