Warfarin and aspirin in patients with heart failure and sinus rhythm.

  title={Warfarin and aspirin in patients with heart failure and sinus rhythm.},
  author={Shunichi Homma and John L. P. Thompson and Patrick M. Pullicino and Bruce Levin and Ronald S. Freudenberger and John R. Teerlink and Susan E Ammon and Susan Graham and Ralph L. Sacco and Douglas L. Mann and Jay P. Mohr and Barry M. Massie and Arthur J. Labovitz and Stefan D. Anker and Dirk J. A. Lok and Piotr P Ponikowski and Conrado J. Estol and Gregory Y. H. Lip and M Di Tullio and Alexandra R. Sanford and Vilma Mej{\'i}a and Andre Gabriel and Mirna L del Valle and Richard Buchsbaum},
  journal={The New England journal of medicine},
  volume={366 20},
BACKGROUND It is unknown whether warfarin or aspirin therapy is superior for patients with heart failure who are in sinus rhythm. METHODS We designed this trial to determine whether warfarin (with a target international normalized ratio of 2.0 to 3.5) or aspirin (at a dose of 325 mg per day) is a better treatment for patients in sinus rhythm who have a reduced left ventricular ejection fraction (LVEF). We followed 2305 patients for up to 6 years (mean [±SD], 3.5±1.8). The primary outcome was… CONTINUE READING
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