Warfarin Therapy That Results in an International Normalization Ratio above the Therapeutic Range Is Associated with Accelerated Progression of Chronic Kidney Disease

@article{Brodsky2010WarfarinTT,
  title={Warfarin Therapy That Results in an International Normalization Ratio above the Therapeutic Range Is Associated with Accelerated Progression of Chronic Kidney Disease},
  author={Sergey V Brodsky and Michael Collins and Edward J. W. Park and Brad H. Rovin and Anjali A. Satoskar and Gyongyi M Nadasdy and Haifeng Wu and Udayan Y. Bhatt and Tibor Nadasdy and Lee A. Hebert},
  journal={Nephron Clinical Practice},
  year={2010},
  volume={115},
  pages={c142 - c146}
}
  • Sergey V Brodsky, Michael Collins, +7 authors Lee A. Hebert
  • Published in Nephron Clinical Practice 2010
  • Medicine
  • Background/Aims: We had previously reported that acute kidney injury (AKI) in warfarin-treated chronic kidney disease (CKD) patients may occur shortly after an acute increase in the International Normalization Ratio (INR) >3.0 with formation of occlusive red blood casts. Recovery from this warfarin-associated AKI is poor. Here we investigated whether excessive warfarin therapy could accelerate the progression of CKD. Methods: We analyzed serum creatinine (SC) and INR in 103 consecutive CKD… CONTINUE READING

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