Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.

@article{Penny2016WarburgMI,
  title={Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.},
  author={Hweixian Leong Penny and Je Lin Sieow and Giulia Adriani and Wei Hseun Yeap and Peter See Chi Ee and Boris San Luis and Bernett Teck Kwong Lee and Terence K W Lee and Shi Ya Mak and Ying Swan Ho and Kong Peng Lam and Choon Kiat Ong and Ruby Y.J. Huang and Florent Ginhoux and Olaf Rotzschke and Roger D Kamm and Siew Cheng Wong},
  journal={Oncoimmunology},
  year={2016},
  volume={5 8},
  pages={e1191731}
}
Patients with pancreatic ductal adenocarcinoma (PDAC) face a clinically intractable disease with poor survival rates, attributed to exceptionally high levels of metastasis. Epithelial-to-mesenchymal transition (EMT) is pronounced at inflammatory foci within the tumor; however, the immunological mechanisms promoting tumor dissemination remain unclear. It is well established that tumors exhibit the Warburg effect, a preferential use of glycolysis for energy production, even in the presence of… CONTINUE READING
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