Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF‐7 breast cancer cells

  title={Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF‐7 breast cancer cells},
  author={Carla Lu{\'i}s and F. Duarte and I. Faria and I. Jarak and P. Oliveira and M. Alves and R. Soares and R. Fernandes},
  journal={Life Sciences},
  • Carla Luís, F. Duarte, +5 authors R. Fernandes
  • Published 2019
  • Chemistry, Medicine
  • Life Sciences
  • Aims Obesity is a complex health disorder and a trigger to many diseases like Diabetes mellitus (DM) and breast cancer (BrCa), both leading causes of morbidity and mortality worldwide. Also evidence demonstrates that abnormal glucose metabolism termed ‘the Warburg effect’ in cancer cell is closely associated with malignant phenotypes and promote the aggressiveness of several types of cancer, including BrCa. In this study, we evaluated the breast cancer cell metabolism in normoglycemia… CONTINUE READING
    6 Citations


    Obesity, metabolism and the microenvironment: Links to cancer
    • 86
    Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer.
    • 38
    Obesity, cholesterol metabolism, and breast cancer pathogenesis.
    • 60
    • PDF
    Adipocyte Secretome Increases Radioresistance of Malignant Melanocytes by Improving Cell Survival and Decreasing Oxidative Status
    • 8
    Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • 1,187
    Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance
    • J. Burns, G. Manda
    • Psychology, Medicine
    • International journal of molecular sciences
    • 2017
    • 57
    • PDF
    Diabetes and cancer: two diseases with obesity as a common risk factor
    • 163
    The underlying basis for obesity: relationship to cancer.
    • G. Bray
    • Biology, Medicine
    • The Journal of nutrition
    • 2002
    • 211
    • PDF
    The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • 862