Walleye Dermal Sarcoma Virus: Molecular Biology and Oncogenesis

  title={Walleye Dermal Sarcoma Virus: Molecular Biology and Oncogenesis},
  author={Joel Rovnak and Sandra L Quackenbush},
Retroviruses have been detected in most vertebrate species and are etiologic agents of a variety of neoplastic diseases. The study of retroviruses has been instrumental in uncovering the molecular mechanisms responsible for oncogenesis. Retroviruses have been isolated from three neoplastic diseases in fish, two of which affect the dermis and regress naturally coincident with spawning. This feature provides a unique model to study mechanisms of tumor development and regression. Three complex… CONTINUE READING