Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study

@inproceedings{Saggu2009WallerianlikeAD,
  title={Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study},
  author={Sarabjit K Saggu and Hiren P Chotaliya and Peter C. Blumbergs and Robert J. Casson},
  booktitle={BMC Neuroscience},
  year={2009}
}
Excitotoxicity is involved in the pathogenesis of a number neurodegenerative diseases, and axonopathy is an early feature in several of these disorders. In models of excitotoxicity-associated neurological disease, an excitotoxin delivered to the central nervous system (CNS), could trigger neuronal death not only in the somatodendritic region, but also in the axonal region, via oligodendrocyte N-methyl-D-aspartate (NMDA) receptors. The retina and optic nerve, as approachable regions of the brain… CONTINUE READING

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