Wallerian degeneration involves Rho/Rho-kinase signaling.

  title={Wallerian degeneration involves Rho/Rho-kinase signaling.},
  author={Satoru Yamagishi and Masashi Fujitani and Katsuhiko Hata and Keiko Kitajo and Fumiaki Mimura and Hideki Abe and Toshihide Yamashita},
  journal={The Journal of biological chemistry},
  volume={280 21},
Local axon degeneration is a common pathological feature of many neurodegenerative diseases, whereas the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involvement of Rho. Nogo-66, a myelin-derived inhibitor of axon regeneration, significantly accelerated axon degeneration of the dorsal root ganglion explant in vitro, whereas inhibiting Rho-kinase activity… CONTINUE READING
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