Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation.

@article{Stoll1989WallerianDI,
  title={Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation.},
  author={Guido Stoll and John Wesley Griffin and Chun Yan Li and Bruce D Trapp},
  journal={Journal of neurocytology},
  year={1989},
  volume={18 5},
  pages={671-83}
}
This study examined the role of Schwann cells and hematogenous macrophages in myelin degradation and Ia antigen expression during Wallerian degeneration of rodent sciatic nerve. To identify and distinguish between macrophages and Schwann cells we used, in addition to electron microscopy, immunocytochemical staining of teased nerve fibres and 1 microns thick cryosections. Before the appearance of adherent macrophages the myelin sheath fragmented into ovoids, small whorls of myelin debris… CONTINUE READING
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