Wallerian Degeneration Involves Rho/Rho-kinase Signaling*

@article{Yamagishi2005WallerianDI,
  title={Wallerian Degeneration Involves Rho/Rho-kinase Signaling*},
  author={S. Yamagishi and M. Fujitani and Katsuhiko Hata and Keiko Kitajo and Fumiaki Mimura and Hideki Abe and T. Yamashita},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={20384 - 20388}
}
  • S. Yamagishi, M. Fujitani, +4 authors T. Yamashita
  • Published 2005
  • Biology, Medicine
  • Journal of Biological Chemistry
  • Local axon degeneration is a common pathological feature of many neurodegenerative diseases, whereas the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons, termed “Wallerian degeneration,” as a model to examine the possible involvement of Rho. Nogo-66, a myelin-derived inhibitor of axon regeneration, significantly accelerated axon degeneration of the dorsal root ganglion explant in vitro, whereas inhibiting Rho-kinase activity… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 16 REFERENCES
    Apoptosis in the nervous system
    1707
    Episodic adaptive evolution of primate lysozymes
    423