Walking to work: roles for class V myosins as cargo transporters

@article{Hammer2012WalkingTW,
  title={Walking to work: roles for class V myosins as cargo transporters},
  author={John A. Hammer and James R. Sellers},
  journal={Nature Reviews Molecular Cell Biology},
  year={2012},
  volume={13},
  pages={13-26}
}
Cells use molecular motors, such as myosins, to move, position and segregate their organelles. Class V myosins possess biochemical and structural properties that should make them ideal actin-based cargo transporters. Indeed, studies show that class V myosins function as cargo transporters in yeast, moving a range of organelles, such as the vacuole, peroxisomes and secretory vesicles. There is also increasing evidence in vertebrate cells that class V myosins not only tether organelles to actin… Expand
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