Walking the interactome for candidate prioritization in exome sequencing studies of Mendelian diseases

Abstract

MOTIVATION Whole-exome sequencing (WES) has opened up previously unheard of possibilities for identifying novel disease genes in Mendelian disorders, only about half of which have been elucidated to date. However, interpretation of WES data remains challenging. RESULTS Here, we analyze protein-protein association (PPA) networks to identify candidate genes… (More)
DOI: 10.1093/bioinformatics/btu508

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Cite this paper

@inproceedings{Smedley2014WalkingTI, title={Walking the interactome for candidate prioritization in exome sequencing studies of Mendelian diseases}, author={Damian Smedley and Sebastian K{\"o}hler and Johanna Christina Czeschik and Joanna S. Amberger and Carol A. Bocchini and Ada Hamosh and Julian Veldboer and Tomasz Zemojtel and Peter N. Robinson}, booktitle={Bioinformatics}, year={2014} }