Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease1

@inproceedings{Chen2014WalkingDA,
  title={Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease1},
  author={Alex Chen and Paul Wilburn and Xin Ping Hao and Tim Tully},
  booktitle={Genes, brain, and behavior},
  year={2014}
}
Parkinson's disease (PD) is a movement neurodegenerative disorder, characterized by bradykinesia, rigidity and tremor, constituting difficulties in walking and abnormal gait. Previous research shows that Drosophila expressing human α-synuclein A30P (A30P) develop deficits in geotaxis climbing; however, geotaxis climbing is a different movement modality from walking. Whether A30P flies would exhibit abnormal walking in a horizontal plane, a measure more relevant to PD, is not known. In this… CONTINUE READING
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