Walker 256 tumor-bearing rats as a model to study cancer pain.

@article{Brigatte2007Walker2T,
  title={Walker 256 tumor-bearing rats as a model to study cancer pain.},
  author={Patr{\'i}cia Brigatte and Sandra Coccuzzo Sampaio and Vanessa Pacciari Gutierrez and Jos{\'e} Luiz Guerra and Id{\'e}rcio Luiz Sinhorini and R Curi and Yara Cury},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2007},
  volume={8 5},
  pages={
          412-21
        }
}
UNLABELLED An animal model of cancer pain induced by injection of Walker 256 carcinoma cells into the plantar surface of rat hind paw is described. Tumor growth and the occurrence of metastasis were investigated by histopathological analysis. Tumor cell growth was also analyzed plethysmographically by the increase in paw volume. For characterization of pain symptoms, hyperalgesia, allodynia, and spontaneous pain were evaluated 5 to 8 days after cell injection. The volume of the inoculated paw… CONTINUE READING

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