Waldenström macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions.

@article{Schop2002WaldenstrmMN,
  title={Waldenstr{\"o}m macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions.},
  author={Roelandt F. J. Schop and Walter Michael Kuehl and Scott A Van Wier and Gregory J. Ahmann and Tammy L. Price-Troska and Richard J Bailey and Syed M Jalal and Ying Qi and Robert A Kyle and Philip R. Greipp and Rafael Fonseca},
  journal={Blood},
  year={2002},
  volume={100 8},
  pages={2996-3001}
}
Lymphoplasmacytic lymphoma (LPL) is characterized by t(9;14)(p13;q32) in 50% of patients who lack paraproteinemia. Waldenström macroglobulinemia (WM), which has an immunoglobulin M (IgM) paraproteinemia, is classified as an LPL. Rare reports have suggested that WM sometimes is associated with 14q23 translocations, deletions of 6q, and t(11;18)(q21;q21). We tested for these abnormalities in the clonal cells of WM patients. We selected patients with clinicopathologic diagnosis of WM (all had IgM… CONTINUE READING
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