Waldenström's macroglobulinaemia: a prospective study comparing daily with intermittent oral chlorambucil.

@article{Kyle2000WaldenstrmsMA,
  title={Waldenstr{\"o}m's macroglobulinaemia: a prospective study comparing daily with intermittent oral chlorambucil.},
  author={Robert A Kyle and Philip R. Greipp and Morie A Gertz and Thomas E Witzig and John A. Lust and Martha Q. Lacy and Terry M. Therneau},
  journal={British journal of haematology},
  year={2000},
  volume={108 4},
  pages={737-42}
}
This prospective study compared continuous and intermittent chlorambucil therapy of untreated Waldenström's macroglobulinaemia. The diagnosis was established by the presence of an IgM monoclonal (M-) protein in the serum, an infiltrate of lymphocytes and plasma cells in the bone marrow, anaemia or other laboratory abnormalities, physical findings or constitutional symptoms. Patients were randomized to receive chlorambucil 0.1 mg/kg/d or chlorambucil 0.3 mg/kg/d orally for 7 d, repeated every 6… CONTINUE READING

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