Waldemar Mordecai Haffkine, CIE (1860–1930): prophylactic vaccination against cholera and bubonic plague in British India

@article{Hawgood2007WaldemarMH,
  title={Waldemar Mordecai Haffkine, CIE (1860–1930): prophylactic vaccination against cholera and bubonic plague in British India},
  author={Barbara J. Hawgood},
  journal={Journal of Medical Biography},
  year={2007},
  volume={15},
  pages={19 - 9}
}
  • B. J. Hawgood
  • Published 1 February 2007
  • Medicine
  • Journal of Medical Biography
Waldemar Mordecai Haffkine developed an anticholera vaccine at the Pasteur Institute, Paris, in 1892. From the results of field trials in India from 1893 to 1896, he has been credited as having carried out the first effective prophylactic vaccination for a bacterial disease in man. When the plague pandemic reached Bombay, Haffkine became bacteriologist to the Government of (British) India (1896–1915). He soon produced an effective antiplague vaccine and large inoculation schemes were commenced… 

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References

SHOWING 1-10 OF 33 REFERENCES
Remarks on Vaccination against Typhoid Fever
TLDR
The method of vaccination which has proved so effectual in combating cholera epidemics in India might be applied also to the prophylaxis of typhoid fever, and the methods which are adopted in preparing the vaccines are described.
Remarks on Haffkine's Method of Protective Inoculation Against Cholera
TLDR
The latter experiments suggest an explanation of those anomalous cases in which a patient has been observed to succumb to a second attack of cholera during the same epidemic, as well as an account of the method employed in the production of the vaccine.
A Lecture on Vaccination Against Cholera
TLDR
The Eastern method has been abandoned in the whole civilised world, and the practice of inoculation against small-pox was originated from the observation that there are mild and severe epidemics of the disease, and that people affected in mild years remained immune in severe years.
Remarks on the Plague Prophylactic Fluid
TLDR
The first condition to be fulfilled for carrying out laboratory work on a microbe is to become able to recognise it with certainty, and to distinguish it from amongst all others which in the course of the work may become associated with it, or eubstitute for it.
On Haffkine's Method of Vaccination against Asiatic Cholera
TLDR
The blood pressure and the respirations remained absolutely unaffected when the chloroform was brought close to the nose and the corneal reflex was entirely abolished, and the respiration gradually quickens up to its previous rate.
Inoculation and the Incubation Stage of Plague
TLDR
The results of experiments with specific antiserums are in striking accord with the Darwinian theory as to the relationships existing between man and apes, the relation of the former, according to that theory, being oloser to the Old World apes.
The Inoculation Accident at Mulkowal
I SHOULD like to Direct the attention of your readers to this matter. The evidence regarding the unfortunate Mulkowal accident, as given in the Lancet and the British Medical Journal for February 2,
Waldemar Haffkine's cholera vaccines and the Ferran-Haffkine priority dispute.
  • G. Bornside
  • Political Science, Medicine
    Journal of the history of medicine and allied sciences
  • 1982
Pasteur, Ferran et Haffkine et l'immunologie a la fin du 19 et au debut du 20 siecle en France et en Russie. La vaccination lors des epidemies en Inde.
Contribution of Haffkine to the concept and practice of controlled field trials of vaccines.
  • B. Cvjetanović
  • Medicine
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1975
TLDR
The rationale for large-scale use of any vaccine in the prevention of an infectious disease lies in the demonstration of its effectiveness in man, and properly designed controlled field trials are required for their evaluation.
The Plague Research Laboratory of the Government of India, Parel, Bombay
Before beginning the account of the present state of the Plague Research Laboratory, it may be interesting to glance rapidly at the history of Mr W. M. Haffkine, C.I.E., its originator and present
...
1
2
3
4
...