Waiting for a compensatory mutation: phase zero of the shifting-balance process.

@article{Phillips1996WaitingFA,
  title={Waiting for a compensatory mutation: phase zero of the shifting-balance process.},
  author={Patrick C Phillips},
  journal={Genetical research},
  year={1996},
  volume={67 3},
  pages={271-83}
}
In highly integrated genetic systems, changes in any one component may have a deleterious effect on fitness, but coordinated, or compensatory, change in these components could lead to an overall increase in fitness compared with the current state. Wright designed his shifting-balance theory to account for evolutionary change in such systems, since natural selection alone can not lead to the new optimal state. A largely untreated aspect of the shifting-balance theory, that of the limiting impact… CONTINUE READING