WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo.

@article{Cunard2002WY14643AP,
  title={WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo.},
  author={Robyn Cunard and Dennis DiCampli and D. Clay Archer and Jennifer L. Stevenson and Mercedes Ricote and Christopher K. Glass and Carolyn J. Kelly},
  journal={Journal of immunology},
  year={2002},
  volume={169 12},
  pages={6806-12}
}
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors with diverse actions. PPARalpha and PPARgamma are expressed in different lymphocyte subpopulations. Recently, we have observed that PPARalpha ligands elicit augmented IL-4 expression in cultures of mitogen-activated splenocytes. The following studies were undertaken to characterize the in vivo effects of WY14,643, a PPARalpha ligand. Our studies demonstrate that oral administration of WY14,643… CONTINUE READING
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