WWP1-dependent ubiquitination and degradation of the lung Krüppel-like factor, KLF2.

  title={WWP1-dependent ubiquitination and degradation of the lung Kr{\"u}ppel-like factor, KLF2.},
  author={Xiaoling Zhang and Seetha V Srinivasan and Jerry B. Lingrel},
  journal={Biochemical and biophysical research communications},
  volume={316 1},
The zinc-finger transcription factor Krüppel-like factor-2 plays an important role in pulmonary development, inhibition of adipocyte differentiation, and maintaining quiescence in single-positive T cells. KLF2 levels rapidly decrease during adipogenesis and activation of T cells, but the pathways involved remain unclear. Previously, we identified WWP1, a HECT-domain E3-ubiquitin ligase, as an interacting partner of KLF2. This led us to speculate that KLF2 may be targeted for ubiquitination… CONTINUE READING