WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

Abstract

WWOX, the gene that maps to common chromosomal fragile site FRA16D, is frequently affected by aberrations in multiple types of cancers. WWOX encodes a 46 kDa protein that contains two WW domains and a short-chain oxidoreductase (SDR) domain. We recently demonstrated that ectopic expression of WWOX inhibits xenograft tumor growth of tumorigenic breast cancer… (More)
DOI: 10.1038/sj.onc.1207680

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