WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

  title={WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ},
  author={S. W. Chan and C. J. Lim and C. Huang and Y. F. Chong and H. J. Gunaratne and K. Hogue and W. Blackstock and K. Harvey and W. Hong},
  pages={600 - 610}
  • S. W. Chan, C. J. Lim, +6 authors W. Hong
  • Published 2011
  • Biology, Medicine
  • Oncogene
  • The transcriptional co-activators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. YAP and TAZ both possess WW domains, which are important protein–protein interaction modules that mediate interaction with proline-rich motifs, most commonly PPXY. The WW domains of YAP have complex regulatory roles as exemplified by recent reports showing that they can positively or negatively influence YAP activity in a cell and context-specific manner. In this study, we show… CONTINUE READING
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