WW domain-containing oxidoreductase: a candidate tumor suppressor.

  title={WW domain-containing oxidoreductase: a candidate tumor suppressor.},
  author={Nan-Shan Chang and Li-Jin Hsu and Y S Lin and F Lai and H. M. Sheu},
  journal={Trends in molecular medicine},
  volume={13 1},
Common fragile site gene WWOX encodes a candidate tumor suppressor WW domain-containing oxidoreductase. Alteration of this gene, along with dramatic downregulation of WWOX protein, is shown in the majority of invasive cancer cells. Ectopic WWOX exhibits proapoptotic and tumor inhibitory functions in vitro and in vivo, probably interacting with growth regulatory proteins p53, p73 and others. Hyaluronidases regulate WWOX expression, increase cancer invasiveness and seem to be involved in the… CONTINUE READING

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