WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators

@article{Leibfried2005WUSCHELCM,
  title={WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators},
  author={Andrea Leibfried and Jennifer P. C. To and Wolfgang Busch and Sandra Stehling and Andreas Kehle and Monika Demar and Joseph J. Kieber and Jan U. Lohmann},
  journal={Nature},
  year={2005},
  volume={438},
  pages={1172-1175}
}
Plants continuously maintain pools of totipotent stem cells in their apical meristems from which elaborate root and shoot systems are produced. In Arabidopsis thaliana, stem cell fate in the shoot apical meristem is controlled by a regulatory network that includes the CLAVATA (CLV) ligand–receptor system and the homeodomain protein WUSCHEL (WUS). Phytohormones such as auxin and cytokinin are also important for meristem regulation. Here we show a mechanistic link between the CLV/WUS network and… 
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Flowering and determinacy in Arabidopsis.
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TLDR
In Arabidopsis, WUSCHEL (WUS) specifies the self-renewing cells at the core of the shoot meristems and is a key target in the control of meristem stability, and these genes participate in a series of regulatory feedback loops that maintain stable expression patterns or promote sharp developmental transitions.
Shoot stem cell specification in roots by the WUSCHEL transcription factor
TLDR
The present research shows that activation of WUS function in the root inhibits the responses to exogenous auxin and suppresses the initiation and growth of lateral roots, and provides evidence for the manner by which WUS specifies stem-cell identity: by affecting auxin responses, by reducing the cell mitotic activity and by repressing other developmental pathways.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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