WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups

@article{Krauth2015WT1MA,
  title={WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups},
  author={M. T. Krauth and Tamara Alpermann and Ulrike Bacher and Christiane Eder and Frank Dicker and Madlen Ulke and Sabrina Kuznia and Niroshan Nadarajah and Wolfgang Kern and Claudia Haferlach and Torsten Haferlach and Susanne Schnittger},
  journal={Leukemia},
  year={2015},
  volume={29},
  pages={660-667}
}
To investigate frequency and prognostic impact of Wilms tumor 1 (WT1) mutations (mut), we analyzed 3157 unselected acute myeloid leukemia patients for WT1mut in exons 7 and 9. In total, 188 WT1 mutations were detected (exon 7: n=150, exon 9: n=38); 141 were frameshift, 24 missense, 14 non-sense, 7 splice site and 2 indel mutations. In 175/3157 (5.5%) patients, a WT1mut was found. Higher frequencies were detected in patients with biallelic CEBPAmut (13.6%; P=0.001), followed by t(15;17)/PML-RARA… CONTINUE READING
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