WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members.

@article{Loeb2006WT1IA,
  title={WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members.},
  author={David Mark Loeb},
  journal={Cell cycle},
  year={2006},
  volume={5 12},
  pages={1249-53}
}
WT1 is a zinc finger transcriptional regulatory protein that has been implicated in both normal development and in the generation of a variety of malignancies. Alternative splicing of the WT1 mRNA results in the expression of four major protein isoforms. There is increasing evidence that one of the functions of WT1 is the regulation of apoptosis, but there are conflicting reports about whether WT1 is pro- or anti-apoptotic. Careful review of the literature suggests that these apparent… CONTINUE READING

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