WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.

@article{Morrison2005WT1IA,
  title={WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.},
  author={Debra J. Morrison and Milton A. English and Jonathan D Licht},
  journal={Cancer research},
  year={2005},
  volume={65 18},
  pages={8174-82}
}
Wilms' tumor or nephroblastoma is believed to arise from embryonic nephrogenic rests of multipotent cells that fail to terminally differentiate into epithelium and continue to proliferate. The WT1 tumor suppressor gene, a transcription factor controlling the mesenchymal-epithelial transition in renal development, is mutated in 10% to 15% of Wilms' tumors. This potentially explains the disordered differentiation and proliferation program of a subset of Wilms' tumors. To elucidate the role of… CONTINUE READING