WT1 expression is inversely correlated with MYCN amplification or expression and associated with poor survival in non-MYCN-amplified neuroblastoma.

@article{Masserot2016WT1EI,
  title={WT1 expression is inversely correlated with MYCN amplification or expression and associated with poor survival in non-MYCN-amplified neuroblastoma.},
  author={Caroline Masserot and Qingyuan Liu and Eric Nguyen and Charles-Henry Gattolliat and Dominique Valteau-Couanet and Jean Pierre Benard and Catherine A Huber and Evelyne S{\'e}gal-Bendirdjian},
  journal={Molecular oncology},
  year={2016},
  volume={10 2},
  pages={
          240-52
        }
}
Neuroblastoma (NB) is the most common extra cranial solid tumor in childhood and the most frequently diagnosed neoplasm during infancy. A striking feature of this tumor is its clinical heterogeneity. Several tumor progression markers have been delineated so far, among which MYCN amplification, which occurs in about 25% of total NB cases, with the percentage increasing to 30% in advanced stage NB. Although MYCN amplification is strongly correlated with NB of poor outcome, the MYCN status cannot… CONTINUE READING
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