WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.

Abstract

Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these cellular decisions is achieved remains elusive. The Wilms' tumour suppressor Wt1 is required for progenitor survival, but the molecular cause for renal agenesis in mutants is poorly understood. Here we… (More)
DOI: 10.1038/ncomms5444

Topics

8 Figures and Tables