WT1 Gene Mutations in Chinese Children With Early Onset Nephrotic Syndrome

@article{Li2010WT1GM,
  title={WT1 Gene Mutations in Chinese Children With Early Onset Nephrotic Syndrome},
  author={Jianguo Li and Jie Ding and Dan Zhao and Zihua Yu and Qingfeng Fan and Yan Chen and Hongwen Zhang and Xuhui Zhong and Jianping Huang and Yong Yao and Hui-jie Xiao},
  journal={Pediatric Research},
  year={2010},
  volume={68},
  pages={155-158}
}
In Chinese children with steroid-resistant nephrotic syndrome (SRNS), it was reported that NPHS2 mutation was detected in 4.3%, which was lower than that in Caucasians (10–30%). However, there were no data on WT1 mutation in nephrotic syndrome (NS), especially in early-onset NS of Chinese children. Thus, a study, which enrolled 36 Chinese children with early-onset (before 3 y old) NS and steroid resistance if failing steroid therapy (early-group), was conducted. As control, 35 children with… CONTINUE READING