WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.

@article{Sugiyama2010WT1T,
  title={WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.},
  author={Haruo Sugiyama},
  journal={Japanese journal of clinical oncology},
  year={2010},
  volume={40 5},
  pages={377-87}
}
Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia. The WT1 gene was originally defined as a tumor suppressor gene, but we proposed that it was, on the contrary, an oncogene. Furthermore, the WT1 protein has proven to be a promising tumor-associated… CONTINUE READING

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