WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

@article{Bozhenok2002WSTFISWICR,
  title={WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.},
  author={Ludmila Bozhenok and Paul A Wade and Patrick D Varga-Weisz},
  journal={The EMBO journal},
  year={2002},
  volume={21 9},
  pages={2231-41}
}
The Williams Syndrome Transcription Factor (WSTF), the product of the WBSCR9 gene, is invariably deleted in the haploinsufficiency Williams-Beuren Syndrome. Along with the nucleosome-dependent ATPase ISWI, WSTF forms a novel chromatin remodeling complex, WICH (WSTF-ISWI chromatin remodeling complex), which is conserved in vertebrates. The WICH complex was purified to homogeneity from Xenopus egg extract and was found to contain only WSTF and ISWI. In mouse cells, WSTF interacts with the SNF2H… CONTINUE READING

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