WSB1: from homeostasis to hypoxia

@inproceedings{Haque2016WSB1FH,
  title={WSB1: from homeostasis to hypoxia},
  author={Moinul Haque and Joseph Keith Kendal and Ryan Matthew MacIsaac and Douglas J. Demetrick},
  booktitle={Journal of Biomedical Science},
  year={2016}
}
The wsb1 gene has been identified to be important in developmental biology and cancer. A complex transcriptional regulation of wsb1 yields at least three functional transcripts. The major expressed isoform, WSB1 protein, is a substrate recognition protein within an E3 ubiquitin ligase, with the capability to bind diverse targets and mediate ubiquitinylation and proteolytic degradation. Recent data suggests a new role for WSB1 as a component of a neuroprotective pathway which results in… CONTINUE READING
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