WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells.

@article{Yong2014WS2NA,
  title={WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells.},
  author={Yuan Yong and Liangjun Zhou and Zhanjun Gu and Liang Yan and Gan Tian and Xiaopeng Zheng and Xiaodong Liu and Xiao Zhang and Junxin Shi and Wenshu Cong and Wenyan Yin and Yuliang Zhao},
  journal={Nanoscale},
  year={2014},
  volume={6 17},
  pages={
          10394-403
        }
}
We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet… 
View on PubMed
doi.org
233 Citations
Highly Influential Citations
2
Background Citations
9
Methods Citations
2
Results Citations
1

Figures from this paper

233 Citations

Citation Type

Citation Type

BSA-exfoliated WSe2 nanosheets as a photoregulated carrier for synergistic photodynamic/photothermal therapy.
TLDR
It was found that dual-mode photothermal and photodynamic therapy has a significant synergistic effect and dramatically improves the therapeutic efficacy toward cancer cells compared with single mode treatment.
WS2 nanosheets functionalized by biomimetic lipids with enhanced dispersibility for photothermal and chemo combination therapy.
TLDR
In vivo photothermal experiments indicated that lipid modification could promote intratumoral accumulation of the material and WS2-lipid can be used as a good nano-platform for phototherapy and chemotherapy combination therapy and has good application prospects in cancer therapy.
Multifunctional WS2 @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.
TLDR
Compared to PTT or GT treatment alone, WS2 @PEI mediated synergistic GT/PTT therapy remarkably enhances in vitro cancer cell damage and in vivo tumor elimination.
One-pot synthesis of AIE based bismuth sulfide nanotheranostics for fluorescence imaging and photothermal therapy.
Effective photodynamic therapy of polymer hydrogel on tumor cells prepared using methylene blue sensitized mesoporous titania nanocrystal.
Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy.
TLDR
ReS2 nanosheets show no obvious toxicity based on the cytotoxicity assay, serum biochemistry, and histological analysis, and could also serve as therapeutic agents for photothermal ablation of tumors with a tumor elimination rate up to 100%.
Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy.
TLDR
A multifunctional nanomedicine based on WS2 quantum dots (QDs) which was prepared by a facile and "green" method through physical grinding and ultrasonication and confirmed that WS2 QDs possess good biocompatibility could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RT to achieve better therapeutic efficacy.
Enhanced Antitumor Efficacy by 808 nm Laser‐Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine‐Green‐Attached W18O49 Nanostructure
TLDR
In vivo animal experiments have shown that WO@ICG has effective solid tumor ablation effect with 808 nm NIR light irradiation, revealing the potential of these nanocomposites as a NIR-mediated dual-modal therapeutic platform for cancer treatment.
Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer
TLDR
In vitro and in vivo experiments confirmed the great biocompatibility, low toxicity and high photothermal conversion capability of K2Mn4O8 as a PTA and would hopefully promote other Mn-based theranostics.
Cu2-xSe/Bi2Se3@PEG Z-scheme heterostructure: a multimode bioimaging guided theranostic agent with enhanced photo/chemodynamic and photothermal therapy.
TLDR
CB3@PEG is endowed with the chemodynamic therapy (CDT) and signal-enhanced T1-weight magnetic resonance imaging (MRI) capacity and the great photothermal ability and X-ray absorption coefficient provide outstanding contrast in photothermal imaging (PTI) and computerized tomography (CT) imaging.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 90 REFERENCES
Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy.
Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy.
Hypocrellin-loaded gold nanocages with high two-photon efficiency for photothermal/photodynamic cancer therapy in vitro.
TLDR
Fluorescence and electronic spin resonance results show that the gold nanocage in the bioconjugate nanostructure can dramatically quench the photosensitizer and inhibit the production of singlet oxygen, which is supposed to alleviate the photosenitizers' unwanted side effects originating from their nontargeted distribution.
Red-emitting upconverting nanoparticles for photodynamic therapy in cancer cells under near-infrared excitation.
TLDR
A new and efficient NIR photosensitizing nanoplatform for PDT based on red-emitting UCNPs is designed, benefiting the fluorescence resonance energy transfer (FRET) fromUCNPs to the attached photosensitizers and thus efficiently activating them to generate cytotoxic singlet oxygen.
Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.
TLDR
The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy.
Photodynamic Characterization and In Vitro Application of Methylene Blue-containing Nanoparticle Platforms¶
TLDR
The concept of the drug-delivering nanoparticles has been extended to a new type of dynamic nanoplatform (DNP) that only delivers 1O2 that could also be used as a targeted multifunctional platform for combined diagnostics and therapy of cancer.
Multifunctional mesoporous silica-coated graphene nanosheet used for chemo-photothermal synergistic targeted therapy of glioma.
TLDR
These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.
Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo.
TLDR
Under the irradiation of 980 nm laser with the conservative and safe power density over a short period, cancer cells in vivo can be efficiently killed by the photothermal effects of the Cu(9)S(5) NCs.
Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy.
TLDR
The potential of using ceramic-based nanoparticles as drug carriers for photodynamic therapy has been demonstrated and the active uptake of drug-doped nanoparticles into the cytosol of tumor cells is demonstrated.
Regulation of singlet oxygen generation using single-walled carbon nanotubes.
TLDR
This study validated the potential of the design as a novel PDT agent with regulation by target molecules, enhanced specificity, and efficacy of therapeutic function, which directs the development of photodynamic therapy to be safer and more selective.
...
1
2
3
4
5
...