WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.

@article{Zecevic2009WRNHP,
  title={WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.},
  author={Alma Zecevic and Haley L Menard and Volkan M Gurel and Elizabeth Hagan and Rosamaria DeCaro and Anatoly Zhitkovich},
  journal={Cell cycle},
  year={2009},
  volume={8 17},
  pages={2769-78}
}
Recent studies in yeast have found that processing of DNA double-strand breaks (DSB) for recombination repair involves Sgs1 helicase. Human cells have five Sgs1 homologues with unknown selectivity and significance for repair of different DSB types. Here we examined the importance of WRN helicase in repair of G(2)-specific DSB caused by abnormal mismatch repair (MMR) of ternary Cr-DNA adducts. We found that Cr(VI) induced a rapid dispersal of WRN from the nucleolus resulting in its prolonged… CONTINUE READING