WRN at telomeres: implications for aging and cancer

@article{Multani2007WRNAT,
  title={WRN at telomeres: implications for aging and cancer},
  author={A. Multani and S. Chang},
  journal={Journal of Cell Science},
  year={2007},
  volume={120},
  pages={713 - 721}
}
  • A. Multani, S. Chang
  • Published 2007
  • Biology, Medicine
  • Journal of Cell Science
  • Werner Syndrome (WS) is a premature aging syndrome characterized by early onset of age-related pathologies and cancer. Since WS is due to a single gene defect, it has attracted much interest from researchers seeking to understand pathways that contribute to cancer and aging at cellular and molecular levels. The protein mutated in WS, WRN, appears to play a major role in genome stability, particularly during DNA replication and telomere metabolism. Much of the pathophysiology associated with WS… CONTINUE READING
    90 Citations

    Figures and Topics from this paper

    Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming
    • 21
    • PDF
    Human premature aging, DNA repair and RecQ helicases
    • 168
    • PDF
    Stem cell aging in adult progeria
    • 6
    Telomerase deficiency and cancer susceptibility syndromes
    • 11
    • PDF
    Telomere dysfunction in human bone marrow failure syndromes

    References

    SHOWING 1-10 OF 128 REFERENCES
    Telomere dysfunction as a cause of genomic instability in Werner syndrome
    • 210
    • PDF
    Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    • 412
    • PDF
    Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes
    • 200
    • PDF
    Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.
    • D. Orren
    • Biology, Medicine
    • Frontiers in bioscience : a journal and virtual library
    • 2006
    • 32
    • PDF
    The Werner syndrome protein at the crossroads of DNA repair and apoptosis
    • L. Comai, B. Li
    • Biology, Medicine
    • Mechanisms of Ageing and Development
    • 2004
    • 39
    • PDF
    Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
    • 1,291
    • PDF
    TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
    • 128
    • Highly Influential
    • PDF
    Deficient DNA repair in the human progeroid disorder, Werner syndrome.
    • V. Bohr
    • Biology, Medicine
    • Mutation research
    • 2005
    • 59
    • PDF
    Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells.
    • 61
    • PDF