WRN at telomeres: implications for aging and cancer

  title={WRN at telomeres: implications for aging and cancer},
  author={A. Multani and S. Chang},
  journal={Journal of Cell Science},
  pages={713 - 721}
  • A. Multani, S. Chang
  • Published 2007
  • Biology, Medicine
  • Journal of Cell Science
  • Werner Syndrome (WS) is a premature aging syndrome characterized by early onset of age-related pathologies and cancer. Since WS is due to a single gene defect, it has attracted much interest from researchers seeking to understand pathways that contribute to cancer and aging at cellular and molecular levels. The protein mutated in WS, WRN, appears to play a major role in genome stability, particularly during DNA replication and telomere metabolism. Much of the pathophysiology associated with WS… CONTINUE READING
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