WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

@article{Chen2003WRNTP,
  title={WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair},
  author={L. Chen and S. Huang and L. Lee and A. Davalos and R. Schiestl and J. Campisi and J. Oshima},
  journal={Aging Cell},
  year={2003},
  volume={2}
}
  • L. Chen, S. Huang, +4 authors J. Oshima
  • Published 2003
  • Biology, Medicine
  • Aging Cell
  • Werner syndrome (WS) predisposes patients to cancer and premature aging, owing to mutations in WRN. The WRN protein is a RECQ‐like helicase and is thought to participate in DNA double‐strand break (DSB) repair by non‐homologous end joining (NHEJ) or homologous recombination (HR). It has been previously shown that non‐homologous DNA ends develop extensive deletions during repair in WS cells, and that this WS phenotype was complemented by wild‐type (wt) WRN. WRN possesses both 3′ → 5′ exonuclease… CONTINUE READING
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