WRAD: enabler of the SET1-family of H3K4 methyltransferases.

  title={WRAD: enabler of the SET1-family of H3K4 methyltransferases.},
  author={Patricia Ernst and Christopher R Vakoc},
  journal={Briefings in functional genomics},
  volume={11 3},
Methylation of histone H3 at lysine 4 (H3K4) is a conserved feature of active chromatin catalyzed by methyltransferases of the SET1-family (SET1A, SET1B, MLL1, MLL2, MLL3 and MLL4 in humans). These enzymes participate in diverse gene regulatory networks with a multitude of known biological functions, including direct involvement in several human disease states. Unlike most lysine methyltransferases, SET1-family enzymes are only fully active in the context of a multi-subunit complex, which… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 86 references

Regulation of MLL1 H3K4 methyltransferase activity by its core components

Nature Structural &Molecular Biology • 2006
View 5 Excerpts
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An Ash 2 L / RbBP 5 heterodimer stimulates the MLL 1 methyltransferase activity through coordinated substrate interactions with the MLL 1 SET domain

P Zhang, H Lee, JS Brunzelle
PLoSOne • 2011

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