WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

@article{Lobov2005WNT7bMM,
  title={WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature},
  author={Ivan B. Lobov and Sujata Rao and Thomas J Carroll and Jefferson E. Vallance and Masataka Ito and Jennifer K. Ondr and Savita Kurup and Donald Alexander Glass and Millan S Patel and Weiguo Shu and Edward E Morrisey and Andrew P. McMahon and Gerard Karsenty and Richard A Lang},
  journal={Nature},
  year={2005},
  volume={437},
  pages={417-421}
}
Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate… CONTINUE READING
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