WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis

@article{Ouyang2014WNT7AAP,
  title={WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis},
  author={H. F. Ouyang and Yuanchao Xue and Ying Lin and Xiaohui Zhang and Lei Xi and Sherrina H. Patel and Huimin Cai and Jing Luo and Meixia Zhang and Ming Zhang and Yang Yang and Gen Li and Hairi Li and Wei Jiang and Emily Yeh and Jonathan Lin and Michelle Pei and Jin Zhu and Guiqun Cao and Liangfang Zhang and Benjamin D-Y Yu and Shaochen Chen and Xiang-Dong Fu and Yizhi Liu and Kang Zhang},
  journal={Nature},
  year={2014},
  volume={511},
  pages={358-361}
}
The surface of the cornea consists of a unique type of non-keratinized epithelial cells arranged in an orderly fashion, and this is essential for vision by maintaining transparency for light transmission. Cornea epithelial cells (CECs) undergo continuous renewal from limbal stem or progenitor cells (LSCs), and deficiency in LSCs or corneal epithelium—which turns cornea into a non-transparent, keratinized skin-like epithelium—causes corneal surface disease that leads to blindness in millions of… CONTINUE READING
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