WNT5a in Tongue and Fungiform Papilla Development

@article{Liu2009WNT5aIT,
  title={WNT5a in Tongue and Fungiform Papilla Development},
  author={Hong-Xiang Liu and A. Grosse and K. Walton and D. Saims and D. Gumucio and C. Mistretta},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1170}
}
Fungiform papillae are complex taste organs that develop in a pattern on anterior tongue in rodent embryos. Several intrinsic secreted molecules are important for papilla development and patterning, including sonic hedgehog, bone morphogenetic proteins, Noggin, epidermal growth factor, and WNTs. Recent data about roles of WNTs in regulation of tongue and fungiform papilla development lead to new insights about the importance of tissue and timing contexts when studying the effects of… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Bone morphogenetic proteins and noggin: inhibiting and inducing fungiform taste papilla development.
Fungiform papillae are epithelial specializations that develop in a linear pattern on the anterior mammalian tongue and differentiate to eventually contain taste buds. Little is known aboutExpand
Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae.
Taste buds on the anterior part of the tongue develop in conjunction with epithelial-mesenchymal specializations in the form of gustatory (taste) papillae. Sonic hedgehog (Shh) and Bone MorphogeneticExpand
Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development.
Taste papillae are ectodermal specializations that serve to house and distribute the taste buds and their renewing cell populations in specific locations on the tongue. We previously showed thatExpand
Development of fungiform papillae: patterned lingual gustatory organs.
The fungiform papilla is a gustatory organ that provides a specific tissue residence for taste buds on the anterior tongue. Thus, during development there must be a progressive differentiation toExpand
Sox2 is required for development of taste bud sensory cells.
Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2Expand
Wnt-β-catenin signaling initiates taste papilla development
Fungiform taste papillae form a regular array on the dorsal tongue. Taste buds arise from papilla epithelium and, unusually for epithelial derivatives, synapse with neurons, release neurotransmittersExpand
Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium.
From time of embryonic emergence, the gustatory papilla types on the mammalian tongue have stereotypic anterior and posterior tongue locations. Furthermore, on anterior tongue, the fungiform papillaeExpand
Wnt-beta-catenin signaling initiates taste papilla development.
Fungiform taste papillae form a regular array on the dorsal tongue. Taste buds arise from papilla epithelium and, unusually for epithelial derivatives, synapse with neurons, release neurotransmittersExpand
Wnt-beta-catenin signaling initiates taste papilla development.
Fungiform taste papillae form a regular array on the dorsal tongue. Taste buds arise from papilla epithelium and, unusually for epithelial derivatives, synapse with neurons, release neurotransmittersExpand
Wnt signaling interacts with Shh to regulate taste papilla development
Wnt and Shh signaling pathways are critical for the development and maturation of many epithelial tissues. Both pathways have roles in stem cell maintenance, tissue development, and tumorigenesis.Expand
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