WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis.

  title={WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis.},
  author={Louis J. Vuga and Ahmi Ben-Yehudah and Elizabetha Kovkarova-Naumovski and Timothy Oriss and Kevin F. Gibson and Carol Feghali-Bostwick and Naftali Kaminski},
  journal={American journal of respiratory cell and molecular biology},
  volume={41 5},
Usual interstitial pneumonia (UIP) is a specific histopathologic pattern of interstitial lung fibrosis that may be idiopathic or secondary to autoimmune diseases and environmental exposures. In this study, we compared gene expression patterns in primary fibroblasts isolated from lung tissues with UIP histology and fibroblasts isolated from lung tissues with normal histology using expression microarrays. We found that WNT5A was significantly increased in fibroblasts obtained from UIP lung… CONTINUE READING
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