WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.

@article{Chassot2012WNT4AR,
  title={WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.},
  author={A. A. Chassot and Stephen T Bradford and Aur{\'e}lie Auguste and Elodie P. Gregoire and Eric A. Pailhoux and Dirk G de Rooij and Andreas Schedl and Marie-Christine Chaboissier},
  journal={Development},
  year={2012},
  volume={139 23},
  pages={4461-72}
}
The gonad arises from the thickening of the coelomic epithelium and then commits into the sex determination process. Testis differentiation is activated by the expression of the Y-linked gene Sry, which promotes cell proliferation and differentiation of Sertoli cells, the supporting cells of the testis. In absence of Sry (XX individuals), activation of WNT/CTNNB1 signalling, via the upregulation of Rspo1 and Wnt4, promotes ovarian differentiation. However, Rspo1 and Wnt4 are expressed in the… CONTINUE READING
20 Citations
85 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 85 references

Similar Papers

Loading similar papers…